I do have VRS Products installed (I think somebody else [with the same error message?] was mentioning that too).
This would have been the next thing that I would say to check, in case reinstalling won't work.
Yes, we suspected this could be an issue, and while we were in Beta, we also had some contacts with VRS, so they sent me their software to try (only the TacPack base module, I don't have any planes that use it), but I couldn't find any problems on my system.
You can try disabling the VRS modules in the DLL.XML and EXE.XML files, by setting the Disabled line as follows:
<Disabled>True</Disabled>
You can try this with another 3rd party modules, to understand if one of them is causing problems to Simconnect data being corrupted somehow, because this is what it seems looking at that error.