Although an FSX user, I have had an on-going problem with Ctrl-Shft-F10 not working. Umberto has seen my evidence of this.
The only solution that I have found is to assign another combination.
You may have to try all combinations that you could imagine until you find one working, including assigning one combination and pressing another. At present I have Ctrl+Shft+f10 assigned, but have to press Ctrl+Shft+P to get it to work.
Until Umberto can try to answer your P3D 2.0 question, you might try my desperation work-around.
Good luck, and do report on your fix when you get one.
Regards, Richard