Hi there!
I recently updated my P3D install from 3.1 (in which GSX worked without any issues) to 3.3.
When I hit the shortcuts (STRG + F12 or Shift + STRG + F12), nothing happens. The entries in the Addons menu within P3D are there, I can also Access the Settings menu of GSX. I updated GSX and the Addon Manager, but still no joy.
Here is the log file, maybe it is helpful for you: