22R almost NEVER has been used for landings. Neither 4L.
Yeah that's true and the same goes for 13R/31L. These runways are used for landings occasionally during off-peak times since 31L/13R and 22R/4L are the only runways used for take off.
Before I closed these runways on my AFCAD, I found myself waiting about 45 minutes before I could takeoff since the departure line was so long and the huge amount of landing traffic was keeping aircraft on the ground from departing.
If you do choose to close both runways, make sure to delete the imaginary runways from the AFCAD or else your AI will not leave their gates.