Nobody has ever reported this problem so far. It might be related to video memory corruption or exhaustion, due to wrong or too high settings or wrong tweaks.
- First try to reset your video driver settings to default. Be sure you don't use "Transparency Antialiasing" (or "Adaptive Anti-aliasing" ).
- If that doesn't work, try to update your video driver too.
- If that doesn't work, try to reset your %APPDATA%\Microsoft\FSX\FSX.CFG file, to have FSX rebuild a new one with default settings
- Be sure you apply the HIGHMEMFIX tweak to the FSX.CFG, you can enabled it with the Addon Manager too, that's the only setting that really needs to be applied.