If you remove the tweak, you will have to set the 4096x4096 resolution using the normal P3D interface.
The end result will be exactly the same: the P3D menu option to set the texture resolution doesn't do anything different than just setting the tweak in the Prepar3d.CFG file, I just wanted to let you know that in Prepar3D you don't have to edit the .CFG file manually to set that parameter, because it allows you to set it with its own interface, which is definitely easier.