Generally, turning off any option to "auto-heal" is good, because even if the antivirus is wrongly identifying a file as a threat, it will at least WARN you and let you decide what to do.
Instead, is not a good idea to permanently turn off scanning your Downloads folder or your Temporary folder, because these are the places where real viruses are usually found.
If the antivirus is still creating issues, is much better to temporarily turn it off entirely, only when *installing*, then turn it back on, with the aforementioned exclusions inside Flight sim enabled, before launching Flight sim.