There's no need to reinstall anything, surely not that would be related to any of the folders you said you used to delete, not sure why. Please clarify more precisely:
- Why you had to remove those folder before, when there wasn't any need.
- Why you thing something has changed now.
- Which simulator you use.
In fact, with the current version, the airport cache ( C:\ProgramData\Virtuali ) is being recreated automatically at each start so, if anything, it should be even less required to remove it.