It still did not work. I have deactivate Virusprogram and it not helps
That's because nowhere I said you should deactivate the antivirus. That won't work because the low-level window service is still running and we experienced first hand they still interfere even if they "look" disabled. That's why I said to add the Addon Manager folder to the antivirus exclusions and NOT disabled it.
GSX is activate in Addon Manager. Nothing happens when I push on the keys Ctrl+F12.
First, the default key for GSX it's CTRL+Shift+F12. If you have another add-on that use that key, you must be sure it's not shared with GSX, since no two add-ons can use the same key.
When I try push on GSX in menu/addon the simulator is closed.
As I've said, it's simply not possible that GSX would close the simulator. Something else is closing the simulator. Perhaps a wrong setting in your video card is causing the sim to crash when an otherwise perfectly normal GSX object is being created, but the problem is the setting, not GSX.
GSX works in P3D V.5.
Clearly proving your problem is some setting in P3D 4.5. Try to remove these folders:
%APPDATA%\Lockheed Martin\Prepar3d V4
%LOCALAPPDATA%\Lockheed Martin\Prepar3d V4
%PROGRAMDATA%\Lockheed Martin\Prepar3d V4
This will restore all settings to default.