I mean using the Flytampa configurator to change options for runway operation or if it should have cars parked on parkings etc.
If the options you changed switched to a different AFCAD, you should pay attention if GSX is Rebuilding the airport cache automatically. If it doesn't, you should probably use the "Restart and Rebuild airport cache" option from the Couatl Settings menu, to be sure GSX will see the changed AFCAD.
If the options you changed didn't changed the AFCAD, it won't affect GSX in any way.