I'm not sure I understand your question: are you saying you would like that FSX would *ignore* the wind, and use a certain runway regardless ? Yes, a runway can be closed for Takeoff or Landing in the AFCAD, you can try that, but what happens if the wind is coming from the wrong side ?
As I've said, FSX select a runway for takeoff or landing depending on MANY factors, the wind being one, but also the availability of an ILS (for landing), the length, the distance from the gate, etc. It's a formula where each parameter has its own weight.